an efficient green approach for the synthesis of structurally diversified spirooxindoles using sulfonic acid functionalized nanoporous silica (sba-pr-so3h)
نویسندگان
چکیده
one-pot multicomponent reaction between isatin, barbituric acid, and 6-amino-1,3-dimethyl uracil was investigated in the presence of sulfonic acid functionalized nanoporous silica (sba-pr-so3h) and resulted in the formation of spirooxindole dipyrimidines. spirooxindole unit is found in many natural products and biologically active molecules and 1,4-dihydropyridines are an important class of compounds with interesting biological activities such as vasolidator, antitumor, antidiabetic, bronchodilator and anti-atherosclerotic activities. excellent yields and short reaction timesare related to the highefficiency of sba-pr-so3h that the reactions take place easily in its nano-pores. mild reaction conditions and easy work-up procedures are other advantages of this green method.
منابع مشابه
An Efficient Green Approach for the Synthesis of Structurally Diversified Spirooxindoles Using Sulfonic Acid Functionalized Nanoporous Silica (SBA-Pr-SO3H)
One-pot multicomponent reaction between isatin, barbituric acid, and 6-amino-1,3-dimethyl uracil was investigated <span style="font-size: 10.0pt; ...
متن کاملApplication of Sulfonic Acid Functionalized Nanoporous Silica (SBA-Pr-SO3H) in the Green One-pot Synthesis of Polyhydroacridine Libraries
1,8-Dioxo-decahydroacridines have been synthesized by the three-component reaction of aromatic aldehydes, aromatic amines (or ammonium acetate), and dimedone in the presence of sulfonic acid functionalized nanoporous silica (SBA-Pr-SO3H) under solvent-free conditions. Excellent yields, short reaction times, mild reaction conditions, an...
متن کاملFacile Knoevenagel condensation Using Sulfonic Acid Functionalized Nanoporous silica (SBA-Pr-SO3H)
Knoevenagel condensation between barbituric acid and aldehyde was investigated in the presence of sulfonic acid functionalized nanoporous silica (SBA-Pr-SO3H) and resulted in the formation of arylidene and bis-arylidene barbiturates. Excellent yields and short reaction times are related to the high efficiency of SBA-Pr-SO3H that the reactions take place easily in its nano-pores. SBA-Pr-SO3H as ...
متن کاملFacile Knoevenagel condensation Using Sulfonic Acid Functionalized Nanoporous silica (SBA-Pr-SO3H)
Knoevenagel condensation between barbituric acid and aldehyde was investigated in the presence of sulfonic acid functionalized nanoporous silica (SBA-Pr-SO3H) and resulted in the formation of arylidene and bis-arylidene barbiturates. Excellent yields and short reaction times are related to the high efficiency of SBA-Pr-SO3H that the reactions take place easily in its nano-pores. SBA-Pr-SO3H as ...
متن کاملapplication of sulfonic acid functionalized nanoporous silica (sba-pr-so3h) in the green one-pot synthesis of polyhydroacridine libraries
1,8-dioxo-decahydroacridines have been synthesized by the three-component reaction of aromatic aldehydes, aromatic amines (or ammonium acetate), and dimedone in the presence of sulfonic acid functionalized nanoporous silica (sba-pr-so3h) under solvent-free conditions. excellent yields, short reaction times, mild reaction conditions, and easy work-up procedures are advantages of this green method.
متن کاملGreen synthesis of bis(indolyl)methanes in water using sulfonic acid functionalized silica (SiO2-Pr-SO3H)
Bis(indolyl)methanes are important group of bioactive metabolites of terrestrial and marine regions. They were synthesized by different methods. Herein, a clean, one-pot synthesis of bis(indolyl)methane derivatives by cyclo-condensation reaction of indole and various aldehydes using Sulfonic acid functionalized silica (SiO2-Pr-SO3H) in aqueous media is reported. The advantages of this new metho...
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عنوان ژورنال:
iranian journal of chemistry and chemical engineering (ijcce)ناشر: iranian institute of research and development in chemical industries (irdci)-acecr
ISSN 1021-9986
دوره 35
شماره 1 2016
میزبانی شده توسط پلتفرم ابری doprax.com
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