an efficient green approach for the synthesis of structurally diversified spirooxindoles using sulfonic acid functionalized nanoporous silica (sba-pr-so3h)

نویسندگان

ghodsi mohammadi ziarani

faezeh aleali

negar lashgari

alireza badiei

چکیده

one-pot multicomponent reaction between isatin, barbituric acid, and 6-amino-1,3-dimethyl uracil was investigated in the presence of sulfonic acid functionalized nanoporous silica (sba-pr-so3h) and resulted in the formation of spirooxindole dipyrimidines. spirooxindole unit is found in many natural products and biologically active molecules and 1,4-dihydropyridines are an important class of compounds with interesting biological activities such as vasolidator, antitumor, antidiabetic, bronchodilator and anti-atherosclerotic activities. excellent yields and short reaction timesare related to the highefficiency of sba-pr-so3h that the reactions take place easily in its nano-pores. mild reaction conditions and easy work-up procedures are other advantages of this green method.

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An Efficient Green Approach for the Synthesis of Structurally Diversified Spirooxindoles Using Sulfonic Acid Functionalized Nanoporous Silica (SBA-Pr-SO3H)

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application of sulfonic acid functionalized nanoporous silica (sba-pr-so3h) in the green one-pot synthesis of polyhydroacridine libraries

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عنوان ژورنال:
iranian journal of chemistry and chemical engineering (ijcce)

ناشر: iranian institute of research and development in chemical industries (irdci)-acecr

ISSN 1021-9986

دوره 35

شماره 1 2016

کلمات کلیدی
[ ' n a n o ' , ' r e a c t o r ' , ' f u n c t i o n a l i z e d s b a ' , 1 5 , ' s p i r o o x i n d o l e d i p y r i m i d i n e s ' , ' i s a t i n ' , ' b a r b i t u r i c a c i d ' ]

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